Changes in bronchial response after Sendai virus infection in guinea pigs
Ohashi, Y.; Motojima, S.; Yamanouchi, K.; Makino, S.
Annals of Allergy 61(2): 109-115
1988
ISSN/ISBN: 0003-4738 PMID: 2840838 Document Number: 314062
Enhanced bronchial reactivity to inhaled histamine was observed in guinea pigs infected with Sendai virus with concomitant decrease of beta-adrenergic receptor density in the pulmonary parenchyma 2 to 3 weeks after the inoculation. Histologic examination of the bronchi showed shedding of epithelial cells with a marked infiltration of mononuclear cells. These observations suggest that damage of the bronchial epithelium and decreased density of beta-adrenergic receptor may be the causes of observed bronchial reactivity.