Pathogenetic mechanisms of the development of cardiac rhythm disorders in the acute period of myocardial infarction
Latoguz, I.K.; Ovcharenko, L.I.; Shapkin, E.I.; Kravchun, P.G.
Kardiologiia 28(2): 38-41
1988
ISSN/ISBN: 0022-9040 PMID: 3373948 Document Number: 313730
The clinical course and biochemical, radioimmune and electrophysiologic findings were assessed in 421 patients with acute myocardial infarction involving heart rhythm and conductivity disorders and 49 patients with acute myocardial infarction, free of cardiac electrical instability. The studies were carried out during arrhythmias and after they were controlled, prior to treatment, at the peak of antiarrhythmic effect of medication, and after a continuous treatment course. Heart rhythm disorders related to acute myocardial infarction were accompanied with a marked response on the part of blood free fatty acids, sympatho-adrenal and kallikrein-kinin activity and carboxycathepsin. Metabolic and neurohumoral changes were eventually reversed and tended to normalize as soon as the sinus rhythm was restored by treatment.