Pathogenetic mechanisms of the development of "hot flushes" in patients with climacteric disorders of the sympathetic-adrenal type
Butareva, L.B.; I'lina, E.M.; Balan, V.E.
Akusherstvo i Ginekologiia 10: 30-33
1989
ISSN/ISBN: 0300-9092 PMID: 2618952 Document Number: 347414
Examinations of 19 patients aged 49 to 55, suffering from climacteric disorders of sympathoadrenal nature, have revealed during 42 hot flushes an activation of the sympathoadrenal section of the autonomic nervous system (increased arterial pressure, heart and respiration rates, and skin galvanic reflex), as well as activation of peripheral vasodilatation, elevated skin temperature, and increased concentrations of LH, ACTH, thyrotropic hormone (TTH), cortisol, aldosterone, and testosterone. These data suggest that the trigger mechanism of a hot flush in the patients with the climacteric syndrome represents modified (due to changes in the external or internal conditions) activity of the LH releasing factor-secreting neuron structures and of the central temperature-sensitive neurons. Activation of the sympathoadrenal section of the autonomic nervous system and of the hypothalamo-hypophyseo-adrenocortical system is explained by their important role in the adaptive reactions of the body. Increase of the TTH level results from increased activity of the thyrotropin releasing factor, contributing to the central mechanisms of thermoregulation.