Nonuniform expression of the dopamine-positive effect in different central m-cholinergic blockaders
Sprints, A.M.; Vinogradov, V.V.; Kolpinskaia, N.D.
Farmakologiia i Toksikologiia 51(2): 36-38
1988
ISSN/ISBN: 0014-8318 PMID: 3378602 Document Number: 313176
In experiments on rats the degrees of the central m-cholinergic blocking (by the ability to suppress arecoline-induced tremor /AT/) and dopamine-potentiating (by potentiation of apomorphine-induced stereotypy (AS] effects of amizyl, glypine, scopolamine and 4-methylpyperidylbenzylate (4-MP) and an esther of phenylcyclopentylglycolinic acid and tropanol (PCT) were compared. It was found that with respect to AS and AT one can distinguish central m-cholinergic blocking agents with milddly (PCT, glypine) and strongly (4-MP, amizyl) dopamine-potentiating properties. None of these compounds administered in the doses corresponding to ED84 by AS influenced nicotine-induced tremor in rats.