Evaluation of the activity of the carbocysteine-sobrerol combination on mucus spinnability
Distefano, S.M.; Palermo, F.; Crimi, N.; Mistretta, A.; Pamparana, F.; Messa, A.
International Journal of Clinical Pharmacology Research 8(1): 31-35
1988
ISSN/ISBN: 0251-1649 PMID: 3284830 Document Number: 311178
Among the rheological properties of bronchial mucus, "spinnability", i.e. the ability to form threads under the effect of traction, should be regarded as the most closely related to the mucociliary transport function. In the present study the "spinnability" parameter was included in the functional tests aimed at evaluating the efficacy of the carboxysteine-sobrerol combination in 16 patients suffering from chronic obstructive lung disease with bronchial hypersecretion. Treatment was administered for ten days under double-blind conditions compared with a placebo. The results obtained showed the tested combination to be able to favourably affect all the most important rheological parameters of mucus, including spinnability, leading to a rapid disappearance of signs and symptoms and to the improvement of the most important respiratory function indexes.
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