The management of cystic fibrosis with carbocysteine lysine salt: single-blind comparative study with ambroxol hydrochloride
Caramia, G.; Gagliardini, R.; Ruffini, E.; Osimani, P.; Nobilini, A.
Journal of International Medical Research 23(4): 284-293
1995
ISSN/ISBN: 0300-0605 PMID: 7589772 Document Number: 447868
The effectiveness of carbocysteine lysine salt monohydrate (SCMC-Lys) and ambroxol hydrochloride (ABX) in the management of respiratory impairment was compared in a single-blind, randomized study of 26 cystic fibrosis patients with similar baseline characteristics. Adults received either SCMC-Lys 900 mg or ABX 33 mg three times a day and children under 14 years of age either SCMC-Lys 270 mg three times a day or ABX 10 mg four times a day. All treatments were given orally for 80 days and at the end of this control period both groups showed significant improvement in chest sound score but improvement in cough score was observed only in those receiving SCMC-Lys. Expectorate viscosity and elasticity decreased significantly in both groups. In SCMC-Lys-treated patients p-aCO-2 decreased and p-aO-2 and Hb O-2 saturation increased while only P-Ao-2 increased significantly in those treated with ABX. An increase in tidal volume, peak expiratory flow values and forced expiratory volume were evident in those receiving SCMC-Lys while significant increases in forced expiratory flow were recorded in those receiving ABX. SCMC-Lys patients' Shwachmann index improved significantly and conversely to the ABX patients. No adverse events were recorded in either treatment group. The study concluded that SCMC-Lys is at least as effective as AB in improving respiratory function in patients with cystic fibrosis.