Characteristics of the course of abscesses during effects on the system of phagocytosing mononuclear cells
Safuan, D.; Koroleva, S.A.; Dorokhova, E.A.; Ermakova, N.G.
Arkhiv Patologii 50(7): 45-51
1988
ISSN/ISBN: 0004-1955 PMID: 3190481 Document Number: 311020
In a series of experiments on 230 noninbred white rats the trend in the development of soft tissue abscess was investigated under stimulation and inhibition of phagocytizing mononuclear cells (PMC). The results suggest the stimulation to promote more reliable localization of the inflammation focus and encapsulation with connective tissue. The test for alpha-naphthyl esterase and quantitation of macrophages (absolute number) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule. The data obtained confirm the assumptions on the role of macrophages in inflammation focus as a regulatory and controlling factor for cellular reactions. PMC system is shown to affect the process of abscess separation from adjacent tissues including formation of the capsule.