Top Abstract Purchase Related
Home
>
Node
>
Subnode

Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells

Horii, Y.; Muraguchi, A.; Suematsu, S.; Matsuda, T.; Yoshizaki, K.; Hirano, T.; Kishimoto, T.

Journal of Immunology 141(5): 1529-1535

1988

ISSN/ISBN: 0022-1767
PMID: 3261753
Document Number: 318075
Regulation of BSF-2/IL-6 production in peripheral mononuclear cells (MNC) was studied. BSF-2 mRNA expression in mitogen-stimulated MNC showed a biphasic response, the first peak around 4 h and the second peak around 48 h. This was caused by different kinetics of BSF-2 mRNA expression in distinct subpopulations of MNC; M phi expressed BSF-2 mRNA at 5 h in the absence of any stimulation, and mitogen-stimulated T cells and B cells expressed BSF-2 mRNA 48 h after stimulation. Immunohistochemical staining of the cells with anti-BSF-2 antibody demonstrated that macrophages, T cells and B cells could produce BSF-2. T cells in peripheral MNC produced BSF-2 in the presence of M phi. The requirement of macrophage for BSF-2 production in T cells could be replaced by TPA but not by IL-1 or BSF-2.

Document emailed within 1 workday
Secure & encrypted payments

Yano, K.; Yamaguchi, M.; de Mora, F.; Lantz, C.S.; Butterfield, J.H.; Costa, J.J.; Galli, S.J. 1997: Production of macrophage inflammatory protein-1alpha by human mast cells: increased anti-IgE-dependent secretion after IgE-dependent enhancement of mast cell IgE-binding ability Laboratory Investigation; A Journal of Technical Methods and Pathology 77(2): 185-193
Levi-Schaffer, F.; Segal, V.; Barak, V.; Rubinchik, E.; Nagler, A. 1997: Regulation of the functional activity of mast cells and fibroblasts by mononuclear cells in murine and human chronic graft-vs.-host disease Experimental Hematology 25(3): 238-245
Bach, M.K.; Brashler, J.R. 1978: Ionophore a 23187-induced production of slow reacting substance of anaphylaxis (SRS-A) by rat peritoneal cells in vitro: evidence for production by mononuclear cells Journal of Immunology 120(3): 998-1005
Oshiba, A.; Gelfand, E.W. 1996: Antigen-dependent regulation of IgE antibody production by human antigen-specific B cells Journal of Immunology 157(11): 4870-4875
Uchiyama, T.; Kamagata, Y.; Yan, X.J.; Kohno, M.; Yoshioka, M.; Fujikawa, H.; Igarashi, H.; Okubo, M.; Awano, F.; Saito-Taki, T. 1987: Study of the biological activities of toxic shock syndrome toxin-1: II. Induction of the proliferative response and the interleukin 2 production by T cells from human peripheral blood mononuclear cells stimulated with the toxin Clinical and Experimental Immunology 68(3): 638-647
Secrist, H.; Holers, V.M.; Levine, A.; Egan, M.; Nahm, M.H.; Butch, A.W.; Peters, M. 1990: Induction of IL-4 and IL-6 synthesis in vitro: variation in signaling requirements and kinetics are dependent on the anatomic source of the responding mononuclear cells Regional Immunology 3(6): 341-348
Halpern, J.; Joy, J.V.; Bielat, K.L.; Ambrus, J.L. 1985: Human peripheral blood mononuclear cells (PBM's) cultured in serum free medium (II): Lymphocyte-macrophage interaction and related morphological changes Journal of Medicine 16(4): 461-482
Romagnani, S.; Maggi, E.; Del Prete, G.F.; Troncone, R.; Ricci, M. 1980: In vitro production of IgE by human peripheral blood mononuclear cells. I. Rate of IgE biosynthesis Clinical and Experimental Immunology 42(1): 167-174
Zhou, Z.; Richard, C.; Ménard, H.A. 2000: De novo synthesis of proteinase 3 by cytokine primed circulating human polymorphonuclear neutrophils and mononuclear cells Journal of Rheumatology 27(10): 2406-2411
Teodorczyk-Injeyan, J.A.; Kellen, J.A. 1988: Chorionic gonadotropin-induced cell proliferation and polyclonal immunoglobulin synthesis in human mononuclear cells Biomedicine and PharmacoTherapy 42(1): 49-53
Probst, H.; Schiffer, H.; Gekeler, V.; Kienzle-Pfeilsticker, H.; Stropp, U.; Stötzer, K.E.; Frenzel-Stötzer, I. 1988: Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo Cancer Research 48(8): 2053-2060
Brostrom, M.A.; Brostrom, C.O.; Brotman, L.A.; Green, S.S. 1983: Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production Molecular Pharmacology 23(2): 399-408
Henández-Guerrero, C.; Vadilllo-Ortega, F.; Beltrán-Montoya, J.; Farina-Granja, M.; Avila-Vergara, M.A.; Bustos-López, H.; Arriaga-Pizano, L. 2001: Induction of nitric oxide synthesis in mononuclear cells in culture using peritoneal fluid from women with endometriosis, in relation to the percentage of T lymphocytes and NK cells identified in an such environment Ginecologia y Obstetricia de Mexico 69: 12-23
Kobayashi, M.; Ohtsuka, K.; Tamura, K.; Ohara, K.; Fujihira, S.; Hirano, Y.; Kusunoki, C.; Hayashi, M.; Satoh, S.; Katayama, N. 1993: Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells Transplantation Proceedings 25(1 Part 1): 655-657
Menegazzi, M.; Carcereri de Prati, A.; Miwa, M.; Suzuki, H.; Libonati, M. 1992: Regulation of poly(ADP-ribose) polymerase gene expression in mitogen-stimulated human peripheral blood mononuclear cells Biochemistry International 26(1): 69-77
Fibbe, W.E.; Daha, M.R.; Hiemstra, P.S.; Duinkerken, N.; Lurvink, E.; Ralph, P.; Altrock, B.W.; Kaushansky, K.; Willemze, R.; Falkenburg, J.H. 1989: Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells Experimental Hematology 17(3): 229-234
Galton, D.J. 1981: The regulation of cholesterol synthesis in human cells International Journal of Obesity 5(6): 619-625
Buttgereit, F.; Brink, I.; Thiele, B.; Burmester, G.R.; Hiepe, F.; Hall, E.D. 1995: Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells Journal of Pharmacology and Experimental Therapeutics 275(2): 850-853
Drapier, J.C.; Hibbs, J.B. 1988: Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells Journal of Immunology 140(8): 2829-2838
Shao, L.; Frigon, N.L.; Sehy, D.W.; Yu, A.L.; Lofgren, J.; Schwall, R.; Yu, J. 1992: Regulation of production of activin a in human marrow stromal cells and monocytes Experimental Hematology 20(10): 1235-1242