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Chromosome analysis of ovocytes and human embryos collected after fertilization in vitro. A model of natural selection against aneuploidy

Plachot, M.; De Grouchy, J.; Junca, A.M.; Mandelbaum, J.; Cohen, J.; Salat-Baroux, J.

Revue Francaise de Gynecologie et d'Obstetrique 83(10): 613-617

1988

ISSN/ISBN: 0035-290X
PMID: 3201050
Document Number: 309497
Fertilization in-vitro offers the possibility of studying the karyotype of ovocytes obtained after superovulation, when they are not fertilized. Among 120 ovocytes, 30 p. cent presented a chromosomal anomaly. The same study was carried out on morphologically normal or abnormal embryos - and the percentage of chromosomal anomalies approximates here 27 p. cent. These studies offer a model of natural selection against chromosomal anomalies and confirm the limiting role of these anomalies in the success of FIV.

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