Studies on the neuropsychopharmacological profile of fengabine (SL 79229) in mice
Aley, K.O.; Kulkarni, S.K.
Methods and Findings in Experimental and Clinical Pharmacology 10(9): 563-568
1988
ISSN/ISBN: 0379-0355 PMID: 3226222 Document Number: 308318
The effect of fengabine (a novel benzylidene derivative) on neuropsychopharmacological parameters was investigated in mice. On acute systemic administration, it showed modulatory effects on 1) forced swimming-induced immobility, 2) foot shock-induced aggression, 3) electromaximal shock-induced convulsion, 4) radiant heat- induced nociception and 5) locomotor activity. However, it has no effect on the muscle strength of the animal. The GABAA receptor antagonists reversed its effects on forced swimming- induced immobility and foot shock-induced aggression, inplicating a GABAergic involvement in its mechanism of action. But these antagonists failed to reverse its potentiating effect on morphine antinociception, suggesting a possible interaction of the drug with opioid receptors. A potential clinical usefulness of the drug and of GABA agonists in general is commented upon.