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Effect of 5-azacytidine on the frequency of polycentric chromosomes in cells with micronuclei during exposure to 5-bromodeoxyuridine

Stobetskiĭ, V.I.; Mironova, L.L.

Biulleten' Eksperimental'noi Biologii i Meditsiny 105(4): 479-480

1988

ISSN/ISBN: 0365-9615
PMID: 2451947
Document Number: 307665
Telomeric fusion of metaphase chromosomes was studied in conditions of DNA hypomethylation induced with 5-azacytidine. It was shown that the increased number of dicentric chromosomes was statistically significant in experiments when 5-azacytidine was used together with colcemid and 5-bromodeoxyuridine. These data demonstrate that DNA hypomethylation plays an important role in the manifestation of this phenomenon.

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