Somatostatin deficiency, hyperinsulinism and thrombocyte aggregation in psoriasis
Neugebauer, D.; Weber, G.
Zeitschrift für Hautkrankheiten 63(7): 585-586; 589-590
1988
ISSN/ISBN: 0301-0481 PMID: 2903597 Document Number: 306067
In 59 patients suffering from chronic psoriasis, we tested the therapeutic effects of yohimbine and colchicine. It is well known that yohimbine, an alpha 2-adrenoceptor-blocking agent, reduces the secretion of insulin and the platelet factors. 85% of our psoriatic patients showed decreased values for somatostatin, in association with hyperinsulinemia (88%) and low platelet counts. Successful therapy with yohimbine resulted in the normalization of the pathological blood levels.