Effect of clopheline on thrombocyte aggregation
Ivleva, A.I.; Baluda, M.V.; Kobalava, Z.D.; Novikova, I.V.; Beloshitskaia, N.I.
Kardiologiia 28(5): 80-83
1988
ISSN/ISBN: 0022-9040 PMID: 2900910 Document Number: 315034
Data on clopheline effect on platelet aggregation, both spontaneous and ADP- or adrenaline-induced, in normal donors are reported. Clopheline is shown to slightly increase aggregation in normal subjects, exhibiting properties of a weak aggregation inductor. Where adrenaline is present in the aggregating system, clopheline undermines its platelet aggregation-inducing effect and, consequently, shows properties of a more competitive antagonist, as compared to adrenaline.