Effect of clopheline on thrombocyte aggregation

Ivleva, A.I.; Baluda, M.V.; Kobalava, Z.D.; Novikova, I.V.; Beloshitskaia, N.I.

Kardiologiia 28(5): 80-83

1988


ISSN/ISBN: 0022-9040
PMID: 2900910
Document Number: 315034
Data on clopheline effect on platelet aggregation, both spontaneous and ADP- or adrenaline-induced, in normal donors are reported. Clopheline is shown to slightly increase aggregation in normal subjects, exhibiting properties of a weak aggregation inductor. Where adrenaline is present in the aggregating system, clopheline undermines its platelet aggregation-inducing effect and, consequently, shows properties of a more competitive antagonist, as compared to adrenaline.

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