Certain mechanisms of the effect of EDTA on thrombocyte aggregation
Suvorov, A.V.; Markosian, R.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 91(5): 587-590
1981
ISSN/ISBN: 0365-9615 PMID: 6266557 Document Number: 169610
Effect of EDTA on the ADP-induced platelet aggregation and intraplatelet regulatory mechanisms were examined. EDTA (and EGTA) was shown to inhibit platelet aggregation and to potentiate the similar effect of theophylline and dibutyryl cAMP. Inhibition of platelet aggregation was seen during incubation of EDTA in conjunction with dibutyryl cAMP at concentrations that did not change the platelet aggregation profile provided the agents cited were incubated alone. Verapamil and tetracain potentiated the inhibitory effect on aggregation of EDTA, dibutyryl cAMP and EDTA plus dibutyryl cAMP.