Somatostatin in a case of neonatal hyperinsulinism caused by focal adenomatosis of the head of pancreas
Pincemaille, O.; Chouraqui, J.P.; Andrini, P.; Jean, D.; Musiedlack, G.; Dyon, J.F.; Rambaud, P.
Archives Francaises de Pediatrie 44(9): 803-805
1987
ISSN/ISBN: 0003-9764 PMID: 2895621 Document Number: 296331
The use of somatostatin in the treatment of a newborn infant with hyperinsulinism is reported. When administered alone, somatostatin was only able to prevent hypoglycemia for a short period of time, whereas the addition of a constant infusion of glucagon allowed successful control of the patient's hypoglycemia. As hyperinsulinism relapsed after a subtotal pancreatectomy, a trial was carried out with a somatostatin analog, which has an expected longer duration of action. It led to a significant rise in the blood glucose level but failed to prevent safely hypoglycemia even when 4 injections were performed daily.