Effects of a intravenous or subarachnoid PGI2 analog (OP-41483) on cerebral and spinal cord blood flow in dogs
Dohi, S.
Masui. Japanese Journal of Anesthesiology 36(11): 1790-1795
1987
ISSN/ISBN: 0021-4892 PMID: 3328793 Document Number: 303131
In order to examine the circulatory effects in CNS of systemic or subarachnoid administration of PGI2 analog (OP-41483) cerebral blood flow (CBF), spinal cord blood flow (SCBF) and cerebrospinal fluid pressure (CSFP) were measured with hydrogen clearance techniques in dogs lightly anesthetized with halothane. OP-41483, 0.2 .mu.g/kg/min, iv, produced approximately 15% increase in both CBF and SCBF associated with a slight decrease in arterial blood pressure and transient increase in CSFP (3.4 .+-. 2.0 mmHg). When OP-41483, 12 .mu.g, 1 ml, was administered into the lumbar subarachnoid space through a catheter in place, neither SCBF nor CBF was affected significantly. These results suggest that although OP-41483 has a vasodilatory action on the normal cerebral and spinal cord vessels and thus increases SCBF as does CBF, its subarachnoid administration can not be expected to have a similar effects on the local SCBF in normal anesthetized dogs.