Effects of rhynchophylline and isorhynchophylline on blood pressure and blood flow of organs in anesthetized dogs
Shi, J.S.; Liu, G.X.; Wu, Q.; Huang, Y.P.; Zhang, X.D.
Zhongguo Yao Li Xue Bao 13(1): 35-38
1992
ISSN/ISBN: 0253-9756 PMID: 1605032 Document Number: 398902
In anesthetized thoracotomized dogs, rhynchophylline (Rhy 5 mg .cntdot. kg-1, iv) reduced the mean arterial pressure (MAP), heart rate (HR), and coronary blood flow (CBF) by 1.16 .+-. s 0.67 kPa, 19 .+-. 12 beats/min, and 0.12 .+-. 0.04 ml .cntdot. min-1 .cntdot. g-1, whereas isorhynchophylline (Isorhy 1 mg .cntdot. kg-1, iv) reduced the parameters by 3.58 .+-. 0.19 kPa, 26 .+-. 18 beats/min, and 0.10 .+-. 0.04 ml .cntdot. min-1 .cntdot. g-1, respectively. In unthoracotomized dogs, Rhy (10 mg .cntdot. kg-1, iv) decreased renal blood flow (RBF) by 0.35 .+-. 0.16 ml .cntdot. min-1 .cntdot. g-1, but did not change the MAP. Isorhy (5 mg .cntdot. kg-1, iv) reduced the MAP by 3.44 .+-. 1.44 kPa, but the RBF remained unaffected. These results indicated that the hypotensive effect of Isorhy in a dosage not affecting RBF was more potent than that of Rhy.