Effect of bacterial toxins on microcirculation (experimental research)
Shalygina, N.B.; Shepeleva, G.K.; Astrina, O.S.; Lomazova, K.D.; Poliakova, A.M.
Arkhiv Patologii 49(2): 27-32
1987
ISSN/ISBN: 0004-1955 PMID: 3105520 Document Number: 301403
Histological and biomicroscopic methods were used to study the effects of toxic lemic and meningococcal microbial fractions on mesenteric blood microcirculation in rats. Aggregation ability of red blood cells and thrombocytes was investigated. The sublethal dose of meningococcal toxins was shown to induce marked impairment in the blood microcirculation 30 minutes after intravenous administration. The lethal dose of lemic toxins manifests itself later (in 2-4 hours). Meningococcal toxins are characterized by the increase in the aggregation ability of erythrocytes and thrombocytes in initial observation periods; lemic toxins increase the thrombocyte aggregation and produce almost no effect on erythrocyte aggregation.