The effect of dalargin on systemic hemodynamics and microcirculation in experimental traumatic shock
Donskikh, E.A.; Kozhevnikova, I.M.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1989(1): 39-42
1989
ISSN/ISBN: 0031-2991 PMID: 2717231 Document Number: 343557
Experiments were conducted on rats and hamster to study the effect of the synthetic analogue of leu-enkephalin dalargin injected in the early phase of traumatic shock. In experiments on hamsters, short-term increase in arterial pressure (AP) and improvement of mircorciurlation occurred in the first minutes after the injection. The AP did increase in rats. This was followed by reduction on AP, deceleration of the blood flow in the microvessels, and increase in the diameter of arterial vessels. These processes developed more rapidly than in the controls. Survival decreased significantly among rats and had a tendency to reduce among hamsters . It is assumed that the inhibiting effect of dalargin in the higher regulaing centres of vegetative functions, which in characteristic of vegetative functions, which in characteristic of opiod peptides, contributed to aggravation of the pathological processes developing in shock and leading to the death of the animals.