Thiol-dependent cytolytic bacterial toxins: streptolysin O and prominent toxins
Alouf, J.E.
Archives de l'Institut Pasteur de Tunis 58(3): 355-373
1981
ISSN/ISBN: 0020-2509 PMID: 6172081 Document Number: 5920
Streptolysin O is the prototype of fifteen bacterial cytolytic protein toxins elaborated by gram-positive bacteria of species Streptococcus, Clostridium, Bacillus and Listeria. These toxins share a number of common properties: they are antigenically related as shown by cross-neutralization and immunoprecipitation; their cytolytic and other reducing agents; these toxins are inactivated by cholesterol and certain related sterols. This group of oxygen-labile cytolytic toxins has been named sulfyhdryl-activated toxins or thiol-activated cytolysins. The mechanism of action of these toxins is very likely identical or at least closely similar.
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