Pharmacokinetics of cefpiramide concentration in lung tissues
Ikeda, T.; Sakai, T.; Nishimura, Y.
Japanese Journal of Antibiotics 40(5): 946-950
1987
ISSN/ISBN: 0368-2781 PMID: 3669289 Document Number: 300402
Concentrations of cefpiramide (CPM) in human lung tissues were determined after 1 g intravenous bolus injection in 6 patients with lung tumors and pyothorax. Concentrations of the CPM in blood and lung tissues were determined and analyzed pharmacokinetically. Levels of CPM in the lung tissues reached 38.4 micrograms/g at 2 hours and declined to 27.7 micrograms/g in 6 hours. Levels of CPM in the lung tissues were higher than 50% of those in the serum between 100 minutes and 360 minutes after the administration of CPM.