Monoclonal antibodies against group a streptococcal polysaccharide reacting with basal-cell antigen of tumors histogenetically related to epidermal tissues
Beletskaia, L.V.; Silagadze, D.G.; Drobyshevskaia, E.I.; Nekrasov, A.V.; Kogan, M.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 103(4): 435-437
1987
ISSN/ISBN: 0365-9615 PMID: 3552071 Document Number: 299758
Immunofluorescence of tumour tissues histogenetically related to tissues containing cross-reacting squamous epithelial basal-cell antigen (BCAg) was performed using monoclonal antibodies (McAb) A6/I-D to squamous epithelial basal-cell antigen cross-reacting with group A staphylococcal polysaccharide. BCAg was found in tumour cells arising from surface tissues of the epidermal type (basal-cell cancer, squamous-cell cancer of the skin, esophagus, cervix uteri and other organs) and was not found in glandular tumours (adenocarcinoma of the stomach, intestine, mammary glands). The results obtained indicate that McAb A6/I-D against cross-reacting BCAg may be used while characterizing the majority of normal epidermal tissues and tumours arising from tissues containing cross-reacting BCAg.