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Monoclonal antibodies reacting with colorectal tumours

Yiu, C.Y.; Baker, L.; Gusterson, B.A.; Ward, M.; Pocock, R.; Summerhayes, I.; Coombes, R.C.; Clark, C.G.

Anticancer Research 6(4): 721-724

1986

ISSN/ISBN: 0250-7005
PMID: 2428281
Document Number: 267835
25 mouse monoclonal antibodies were screened for cell surface reactivity with tumours using the indirect immunoperoxidase method. Five antibodies of the IgG subclasses were selected. LICR-LON-M8 was raised against human milk fat globule membrane (HMFGM). The remaining four antibodies 48-1, 3-48-2, 77-1, and 8-30-3 were raised against human bladder metastases. M8, 77-1 and 8-30-3 which showed epithelial membrane antigen (EMA)-like reactivity exhibited greater selectivity for colorectal cancer compared with normal colon. M8 and 77-1 are being evaluated for immunoscintigraphy of colorectal carcinoma.

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