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Degradation of thialysine- or selenalysine-containing abnormal proteins in CHO cells

Di Girolamo, M.; Busiello, V.; Di Girolamo, A.; De Marco, C.; Cini, C.

Biochemistry International 15(5): 971-980

1987

ISSN/ISBN: 0158-5231
PMID: 3124854
Document Number: 299332
CHO cells can incorporate thialysine and selenalysine in their proteins in substitution of lysine. Data are reported in the present paper showing that proteins containing either thialysine or selenalysine are unstable and quite rapidly degraded. The degradation rate is strictly related to the extent of protein lysine substitution. At similar extent of substitution, selenalysine-containing proteins are more unstable than thialysine-containing ones.

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