Experimental study of the antihypoxic properties of ibuprofen and other nonsteroidal anti-inflammatory preparations
Mashkovskiĭ, M.D.; Bobkov, I.G.; Shvarts, G.I.; Ivanova, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 103(6): 688-690
1987
ISSN/ISBN: 0365-9615 PMID: 3593952 Document Number: 298747
The antihypoxic properties of ibuprofen, diclofenac sodium, acetylsalicylic acid and phenylbutazone have been studied. Ibuprofen significantly increases survival of mice in the model of hypoxic hypoxia with hypercapnia. In addition, ibuprofen and diclofenac sodium possess antihypoxic protective activity in the models of circulatory and anoxic hypoxia in rats.