Nephrotoxicity of nonsteroidal anti-inflammatory drugs
Baisac, J.; Henrich, W.L.
Mineral and Electrolyte Metabolism 20(4): 187-192
1994
ISSN/ISBN: 0378-0392 PMID: 7845321 Document Number: 437409
Nonsteroidal anti-inflammatory drugs (NSAIDs) are important therapeutic agents in the management of rheumatologic disorders and other pain syndromes. Over the counter availability of the drugs has expanded the usage of the drugs. This article reviews the nephrotoxicity of these drugs, with some emphasis on NSAID-related proteinuria. Although reversibility of renal involvement upon drug discontinuance is the rule, progression to end-stage renal disease has occurred. A proposed guideline for monitoring renal impairment in low- and high-risk patients is also presented.