Use of nonsteroidal anti-inflammatory drugs in diabetic retinopathy
Malukiewicz, G.; Stafiej, J.; Lesiewska, H.; Sikorski, B.
Klinika Oczna 118(1): 44-47
2016
ISSN/ISBN: 0023-2157 PMID: 29715408 Document Number: 686234
Diabetic macular edema, a manifestation of diabetic retinopathy, occurs more frequently in type 2 diabetes mellitus. There is evidence that inflammation plays a prominent role in the pathogenesis. A number of pro-inflammatory cytokines are consistently elevated in the vitreous of patients with advanced stages of diabetic retinopathy. Nonsteroidal anti-inflammatory drugs inhibit the catalytic activity of the cyclooxygenase isoenzymes COX-1 and COX-2, the key enzymes in inflammatory processes. To present current knowledge of benefits and limitations of using nonsteroidal anti-inflammatory drugs in diabetic retinopathy. Nonsteroidal anti-inflammatory druds may be considered as an adjuvant treatment in diabetic retinopathy especially in patients with diabetic macular edema.