Effect of gamma-oxybutyrate on energy metabolism and the cyclic nucleotide level in nerve tissue in experimental intracerebral hemorrhage
Maslov, L.N.; Maslova, L.V.; Balabanov, A.V.; Zamotrinskiĭ, A.V.; Lishmanov, I.B.
Farmakologiia i Toksikologiia 50(3): 90-92
1987
ISSN/ISBN: 0014-8318 PMID: 3609288 Document Number: 298720
Experimental intracerebral hemorrhage (EICH) was shown to cause a disorder of the functional state of the brain mitochondria. The rate of oxidation of NAD- and FAD-linked substrates in 3 and 4 states decreased 1 and 24 hours after hemorrhage. An injection of gamma-hydroxybutyrate 1 hour before decapitation increased the rate of mitochondrial respiration. EICH was found to increase cGMP level and to decrease cAMP level. A combined action of hemorrhage and gamma-hydroxybutyrate produced a greater lowering of cAMP level and an elevation of cGMP level.