Comparative study of the treatment of simple urinary infection with a single dose of norfloxacin versus cotrimoxazole
De Vevey, P.; Darioli, R.; Bille, J.; Glauser, M.P.
Schweizerische Medizinische Wochenschrift 117(25): 968-973
1987
ISSN/ISBN: 0036-7672 PMID: 3497450 Document Number: 298056
53 women with acute, uncomplicated urinary tract infection proven clinically and bacteriologically were treated, after double-blind randomisation, with a single dose of norfloxacin (1200 mg) or a single dose of cotrimoxazole (480/2400 mg). Follow-up one week after treatment showed a comparable success rate (85%) for both antibiotics. Only few minor side effects were recorded in both patient groups. Most failures were due to gram positive bacteria (coagulase-negative staphylococci). These results suggest that single dose therapy for urinary tract infections due to gram positive germs should be reconsidered.