Comparative study of the efficacy of captopril at a single daily dose of 100 mg and at a twice daily dose of 50 mg by measuring ambulatory pressure over 24 hours
De Gaudemaris, R.; Battistella, P.; Siche, J.P.; Debru, J.L.; Blatier, J.F.; Mallion, J.M.
Postgraduate Medical Journal 62 Suppl. 1: 97-100
1986
ISSN/ISBN: 0032-5473 PMID: 3534869 Document Number: 280768
Variations in blood pressure were investigated by an automatic, non-invasive ambulatory method in 9 subjects with essential hypertension. Recordings were made after 6 week periods during which captopril was taken either once or twice daily, in a double-blind cross-over study. Although the effects of captopril administration either once or twice daily were broadly similar, there was a significant decrease in diastolic blood pressure values on the once-daily regimen. These results suggests that treatment once a day can advantageously replace twice-daily treatment.