Effect of a single dose of mesoglycan on the human fibrinolytic system, and the profibrinolytic action of nine daily doses
Vittoria, A.; Messa, G.L.; Frigerio, C.; Celasco, G.; Auteri, A.
International Journal of Tissue Reactions 10(4): 261-266
1988
ISSN/ISBN: 0250-0868 PMID: 2977981 Document Number: 306266
The profibrinolytic activity or orally administered Mesoglycan was evaluated in 18 patients affected by impaired plasma fibrinolytic activity, Mesoglycan was administered by a single oral dose of 24, 48 or 72mg on 1 day, and be repeated doses of 48 mg twice a day for 9 consecutive days. After the single administration all the fibrinolytic parameters were significantly and positively influenced with an order of magnitude and a duration of effects proportional to the dose employed. After the repeated administration, a constant and reproducible activation of the fibrinolytic system was observed without any interference with haemocoagulative parameters. These results confirm that Mesoglycan is endowed with a relevant profibrinolytic activity in man after oral administration. The pharmacological activity of Mesoglycan could possibly involve the liberation of a certain amount of plasminogen tissue activator.