Treatment of acute brucellosis with cotrimoxazole, doxicyclin and streptomycin. A comparative study
Vargas, V.; Pedreira, J.D.; Clotet, B.; Juste, C.; Guardia, J.; Bacardi, R.
Medicina Clinica 75(10): 418-420
1980
ISSN/ISBN: 0025-7753 PMID: 7007755 Document Number: 160687
Human brucellosis can be managed with different therapeutic measures. The therapeutic efficacy of the classical treatment with streptomycin, chlortetracycline and sulfadiazine with the association of streptomycin, doxycycline and co-trimoxazole were compared. Each of the treatment regimes was applied to 19 patients with acute brucellosis. The results do not demonstrate an advantage of the new association over the classical treatment. Relapses, time elapsed until the patient was afebrile and drug tolerance were similar for both treatments. The classical treatment has a lower cost but the new association implies more patient comfort because the number of pills to be ingested daily is reduced to less than half, a fact that could make it the treatment of choice.