Use of phospholipids to repair rat liver membranes during carbon tetrachloride poisoning
Dobrynina, O.V.; Migushina, V.L.; Shatinina, S.Z.; Boldanova, N.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(9): 301-303
1987
ISSN/ISBN: 0365-9615 PMID: 3663914 Document Number: 297108
The effect of phospholipid multilayer liposomes on the properties of endoplasmic reticular membranes has been studied in hepatic cells damaged with CCl4. It has been shown that the repair effect of phosphatidylcholine liposomes was manifested in vivo by normalization of phospholipid membrane composition, reduction in the degree of cytochrome P-450 inactivation, partial normalization of its hydroxylase activity and recovery of glucose-6-phosphatase activity. The degree of phosphatidylcholine unsaturation, and the introduction of antioxidants--SH-compounds, sphingomyelin, phosphatidyl inositol--into liposomes did not influence the efficacy of liposomes.