Effect of ethylxanthogenate, diethyldithiocarbamate and unithiol on carbon tetrachloride poisoning
Stoytchev, T.; Kirova, A.
Acta Physiologica et Pharmacologica Bulgarica 3(1): 61-69
1977
ISSN/ISBN: 0323-9950 PMID: 197792 Document Number: 116998
Studies were made on effects of potassium ethylxanthogenate (PEX), diethyldithiocarbamate (DDC) and unithiol on CCl4 poisoning. PEX applied i.p. had a considerably better antidotal effect compared with an equimolar dose of Na DDC in cases of acute oral CCl4 poisoning. Unithiol had no antidotal effect. In cases of 100% lethality among controls, PEX applied orally in doses of 80.2 mg/kg and 160.4 mg/kg, saved all animals. The antidotal effect of oral PEX administration was most pronounced for the dose of 80.2 mg/kg. Reduction of the dose decreased the antidotal effect, which remained present, although very weak, even in a dose of 5 mg/kg. A dependence of the PEX antidotal effect on the time of its application in the case of oral CCl4 poisoning of rats was observed. Best antidotal effect is obtained when the 1st PEX injection is made of 1 h before CCl4, weaker upon simultaneous administration and considerably poorer when PEX was applied 1 h after CCl4. No antidotal effect was found if PEX was applied 3 h after CCl4. In cases of CCl4 i.p. poisoning the rats die much fater (until the 24th h) compared with oral poisoning with the same dose. PEX had practically no antidotal effect, while the antidotal effect of DDC was considerably weaker compared with oral poisoning. Activity of serum glutamate-oxaloacetate-transaminase (SGOT) and serum glutamate-pyruvate-transaminase (SGPT) in cases of CCl4 poisoning in rats increased more than 13 times for SGOT and more than 25 times for SGPT. PEX applied twice in a dose of 80.2 mg/kg orally caused complete normalization of enzyme activity.