Decrease in the c-myb gene transcript during differentiation of mouse teratocarcinoma stem cells
Fukuda, M.; Ikuma, S.; Setoyama, C.; Shimada, K.
Biochemistry International 15(1): 73-79
1987
ISSN/ISBN: 0158-5231 PMID: 2840075 Document Number: 296650
Transcript of the c-myb gene, one of the proto-oncogenes, was clearly detected in undifferentiated mouse F9 teratocarcinoma stem cells, but not in terminally differentiated mouse parietal endoderm PYS-2 cells. As F9 cells can be induced to differentiate into parietal endoderm-like cells by the addition of retinoic acid and dibutyryl cAMP, we examined levels of the c-myb transcript under this experimental condition and found that the c-myb transcript was decreased significantly. Thus, a decrease in the c-myb transcript is probably related to early differentiation of mammalian cells.