Intracellular amino acid concentrations in various disease states
Roth, E.; Karner, J.
Infusionstherapie und Klinische Ernahrung 14(4): 147-150
1987
ISSN/ISBN: 0378-0791 PMID: 3679517 Document Number: 295681
The determination of free amino acids (AA) in human tissue is far more complicated than the analysis of plasma AA. The concentrations of free AA are different in plasma, liver and muscle, respectively. Pathological conditions like sepsis, liver failure and glucagonoma syndrome lead to characteristic alterations in the concentrations of free AA. However, the relationship between cytosolic AA concentrations and protein synthesis are not yet clear. Possibly drastically reduced levels of single AA (e.g. glutamine) lead to a 'down'-regulation of protein synthesis.