Trypanosoma cruzi (CL strain) infection in mice changes the chronotropic effect of isoproterenol in vitro
Pires, J.G.; Pereira, F.E.
Brazilian Journal of Medical and Biological Research 20(3-4): 445-447
1987
ISSN/ISBN: 0100-879X PMID: 2837299 Document Number: 295305
Isoproterenol (IP) was used to investigate the in vitro chronotropic sensitivity of atrial beta-adrenoceptors from mice acutely (30 days) or chronically (180 days) infected with T. cruzi, CL strain (a myotropic strain). Displacement of the dose-response curve to IP to the right occurred in the acute phase group. In the chronic phase group the opposite effect occurred (hyperreactivity to IP) although to a lesser extent. These results suggest that infection of mice with this strain of T. cruzi induces quantitative or qualitative changes in atrial beta-adrenoceptors.