Combination chemotherapy and hormonal therapy in the treatment of malignant melanoma
McClay, E.F.; Mastrangelo, M.J.; Bellet, R.E.; Berd, D.
Cancer Treatment Reports 71(5): 465-469
1987
ISSN/ISBN: 0361-5960 PMID: 3567970 Document Number: 294066
Twenty-three patients with metastatic melanoma were treated with combination therapy consisting of decarbazine (220 mg/m2) and cisplatin (25 mg/m2) iv daily for 3 days every 3 weeks, carmustine (150 mg/m2) iv every 6 weeks, and tamoxifen (10 mg) orally twice daily. In 20 evaluable patients, there were no complete responses and ten partial responses. The median remission duration has not yet been reached but exceeds 7 months. Treatment was relatively well tolerated. However, six patients developed deep venous thrombosis, and four of these six suffered pulmonary emboli. Our data support a previous study and suggest that this combination warrants comparison with the active single components in a randomized prospective trial.