Comparative evaluation of three combination regimens for advanced malignant melanoma: results of an international cooperative study
Beretta, G.; Bonadonna, G.; Cascinelli, N.; Morabito, A.; Veronesi, U.
Cancer Treatment Reports 60(1): 33-40
1976
ISSN/ISBN: 0361-5960 PMID: 1000518 Document Number: 108912
The therapeutic results of a controlled study with three multiple-drug regimens (regimen A: DTIC, vincristine, BCNU; regimen B: DTIC, vincristine, hydroxyurea; and regimen C: DTIC, actinomycin D, BCNU) in a total of 274 evaluable patients with advanced malignant melanoma are reported. CRs were significantly more frequent (P less than 0.01) in regimens A (9.3%) and C (16.4%) compared with regimen B (1.1%). No significant difference in terms of CR plus PR was detected among the three regimens. In all regimens a higher number of CRs plus PRs was seen in patients with soft tissue metastases only, compared with those who had visceral involvement. In all three regimens patients achieving CR showed a longer duration of response and survival in comparison with patients achieving PR. The incidence of brain metastases was neither lowered nor delayed by the presence of BCNU in regimens A and C.