The effects of intracerebral norfenfluramine on body temperature of the rat
Kruk, Z.L.
Journal of Pharmacy and Pharmacology 28(11): 841-842
1976
ISSN/ISBN: 0022-3573 PMID: 11296 Document Number: 108911
When injected by the intracerebroventricular route, fenfluramine is inactive in causing a fall in body core temperature accompanied by a rise in skin temperature. The metabolite of fenfluramine-norfenfluramine is active in this respect, the fall in core temperature and rise in skin temperature being dose-dependent. When the effects of fenfluramine and norfenfluramine administered intracerebrally are examined for their anorectic activity, results analagous to those for body temperature changes are seen. The consistent demonstration that when applied directly into the CNS, norfenfluramine is active and fenfluramine is not active, argues in favor of the suggestion that the CNS responses observed in vivo following administration of fenfluramine are due to the active metabolite norfenfluramine.