Value of rapid diagnosis of Plasmodium falciparum using indirect monoclonal immunofluorescence

Deletoille, P.; Prou, O.

Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 80(3 Part 2): 569-580

1987


ISSN/ISBN: 0037-9085
PMID: 2446789
Document Number: 292736
Development and use of murine specific monoclonal antibodies associated with an indirect immunofluorescent assay allows a rapid detection of P. falciparum antigens. This work compares the results obtained by interpretation of Giemsa staining technique on blood smears, to the use of a commercial reagent (Monofluo Kit P. falciparum). This monoclonal indirect immunofluorescent assay (I.F.I.M.) provides the clinician with a precious aid to diagnosis as well by its specificity and sensitivity, better than conventional staining techniques; particularly in pauciparasitaemia induced by prime-infestation or partial anti-malarial drug resistance.

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