Effect of camphoramine chloroacetic platinum (CCP) on biomacromolecules in L1210 leukemic cells
Wang, L.G.; Liu, X.M.; Ji, X.J.
Yao Xue Xue Bao 22(2): 87-92
1987
ISSN/ISBN: 0513-4870 PMID: 3618241 Document Number: 292448
Camphoramine Chloroacetic Platinum (CCP) is a new anticancer platinum complex. In the present paper, the effects of CCP on contents and biosynthesis of DNA, RNA and proteins of L1210 leukemic cell in DBA/2 mice and the mode of action of CCP on DNA template by using isotope and fluoresent probe techniques are reported. Preliminary results revealed that CCP decrease the contents of DNA, RNA and proteins of L1210 leukemic cell in vivo and in vitro and has remarkable inhibition on biosynthesis of DNA in L1210 cell. The action of CCP may be to damage the DNA template and bind to DNA covalently and noncovalently.