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Antineoplastic action of prostaglandin D2--effect of PGD2 on proliferation of L1210 leukemic cells in culture

Fukushima, M.; Kato, T.; Ota, K.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(1): 159-160

1982

ISSN/ISBN: 0385-0684
PMID: 6964030
Document Number: 187301
Prostaglandin D2 was found to have a potent cytotoxic effect on L1210 leukemia culture cells. When Prostaglandin D2 was added to the culture medium, at the concentration of over 5 micrograms/ml growth of L1210 cells was almost completely inhibited. IC50 of Prostaglandin D2 for L1210 cell was 2.4 micrograms/ml. Cells exposed this agent showed remarkable change in its cytoplasm with many vacuoles and lysis of cells were observed at the concentration over 5 micrograms/ml.

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