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Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture

Kuttan, R.

Indian Journal of Physiology and Pharmacology 31(4): 245-249

1987

ISSN/ISBN: 0019-5499
PMID: 2836309
Document Number: 301988
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state there was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.

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