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Probenecid inhibition of the renal excretion of dyphylline in chicken, rat and man

Acara, M.; Carr, E.A.; Terry, E.N.

Journal of Pharmacy and Pharmacology 39(7): 526-530

1987

ISSN/ISBN: 0022-3573
PMID: 2886621
Document Number: 290745
The effect of probenecid on the renal excretion of dyphylline was studied in chicken, rat and man. Dyphylline was found to be actively excreted when measured by the Sperber preparations in hens, the isolated perfused kidney of the rat and clearance studies in man. In each study probenecid significantly decreased dyphylline excretion demonstrating that dyphylline occupied the renal organic anion transport system. This same drug interation, at the level of the renal excretory system, in these three species occurred at comparable concentrations of dyphylline and probenecid.

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