Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux
Sirotnak, F.M.; Moccio, D.M.; Young, C.W.
Cancer Research 41(3): 966-970
1981
ISSN/ISBN: 0008-5472 PMID: 7459883 Document Number: 176296
Carrier-mediated influx and efflux of Ehrlich carcinoma cells. These results have pharmacological implications with respect to the adjuvant use of probenecid or related organic ions during folate analog therapy of human cancer.
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