Diflunisal renal clearance in anesthetized dogs: effect of probenecid, urine flow, and urine pH
Baer, J.E.; Breault, G.O.; Russo, H.F.
Archives Internationales de Pharmacodynamie et de Therapie 235(2): 204-210
1978
ISSN/ISBN: 0003-9780 PMID: 32854 Document Number: 135414
Using conventional clearance technique, the net renal clearance of diflunisal is very low, about 1% of glomerular filtration rate. Although net renal secretion is not demonstrable, probenecid significantly decreased renal clearance of the drug. Also, the renal clearance was increased by increases in urine flow or urinary pH. In contrast to acetylsalicylic acid, these effects would be expected to be minor, on the one hand to conserve drug or on the other hand in facilitating drug elimination in cases of overdosage.