Dependency on sex hormone in human esophageal cancer--measurement of the androgen receptor in resected specimens
Yamashita, Y.; Hirai, T.; Miyoshi, Y.; Ohtagaki, S.; Mukaida, H.; Toge, T.; Niimoto, M.; Hattori, T.
Gan no Rinsho. Japan Journal of Cancer Clinics 33(11): 1303-1308
1987
ISSN/ISBN: 0021-4949 PMID: 3669316 Document Number: 289330
Clinically it is well known that the incidence of esophageal cancer is much higher in men that in women. Further, the prognosis of the esophageal cancer is worse for men than for women. This seems to be dependent on the difference of environment of the sex steroid. In this paper, the androgen receptor (AR) has been measured in 21 cases of human esophageal cancer. Two cases of esophageal cancer that were implanted into nude mice were AR positive. In this EH-1 cell line, the binding sites were increased and the tumor growth was enhanced by testosterone administration, but the tumor growth was not inhibited by estrogen administration.