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Differential regulation of androgen receptor promoter in hormone-sensitive and -insensitive prostate carcinoma cells

Kopp, H.; Masters, J.R.; Wieland, W.; Hofstaedter, F.; Buettner, R.

Verhandlungen der Deutschen Gesellschaft für Pathologie 77: 129-132

1993

ISSN/ISBN: 0070-4113
PMID: 7511270
Document Number: 418319
The sensitivity of prostate epithelial cells to androgens is mediated by the androgen receptor (AR). Analyses of cell lines in vitro and prostate carcinomas in vivo provide evidence that loss of AR expression parallels the loss of sensitivity to androgens. The aim of our work is to analyze the genetic control elements of the AR gene and answer the question of why these elements fail to function in hormone-insensitive prostate cancer cells. Therefore, we have cloned and fully sequenced a 5700 base pair sequence 5'-upstream of the AR gene. This DNA fragment contains promoter and enhancer elements that are active in androgen-sensitive but inactive in androgen-insensitive prostate cancer cell lines.

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Jarrard, D.F.; Kinoshita, H.; Shi, Y.; Sandefur, C.; Hoff, D.; Meisner, L.F.; Chang, C.; Herman, J.G.; Isaacs, W.B.; Nassif, N. 1998: Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells Cancer Research 58(23): 5310-5314
Izbicka, E.; MacDonald, J.R.; Davidson, K.; Lawrence, R.A.; Gomez, L.; Von Hoff, D.D. 1999: 5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells Anticancer Research 19(2a): 1285-1291
Colburn, N.H.; Smith, B.M.; Wendel, E.J.; Dowjat, W.K.; Shimada, T. 1988: Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells Cancer Research 48(5): 1195-1200
Chen, W.; Yan, C.; Pu, J.; Hou, J.; Wen, D.; Guo, Z. 2004: Regulation of EGF-receptor expression by TGFalpha in human prostate androgen-unresponsive cancer cells Zhonghua Nan Ke Xue 10(8): 595-597
Alvarez Rodríguez, S.; Alonso Gordoa, T.; Burgos Revilla, F.Javier. 2018: Current status of androgen deprivation therapy in hormone-sensitive prostate cancer Archivos Espanoles de Urologia 71(3): 247-257
Gao, J.; Isaacs, J.T. 1998: Development of an androgen receptor-null model for identifying the initiation site for androgen stimulation of proliferation and suppression of programmed (apoptotic) death of PC-82 human prostate cancer cells Cancer Research 58(15): 3299-3306
Vagundova, M.; Vagunda, V.; Vermousek, I.; Rovny, A. 2003: Androgen receptor in prostate carcinoma: immunohistochemical and ligand saturation analyses Neoplasma 50(4): 287-290
Pettaway, C.A. 1999: Racial differences in the androgen/androgen receptor pathway in prostate cancer Journal of the National Medical Association 91(12): 653-660
Bastos, D.A.; Dzik, C.; Rathkopf, D.; Scher, H.I. 2014: Expanding androgen- and androgen receptor signaling-directed therapies for castration-resistant prostate cancer Oncology 28(8): 693-699
Liu, B.-d.; Feng, Q.-q.; Gu, X.; Lu, D.; Li, W. 2015: Effects of triptolide on the expression of androgen receptor in human prostate LNCaP cells and its mechanism of action Yao Xue Xue Bao 50(10): 1246-1251
Pan, T.-F.; Liang, C.-Z.; Chen, X.-G.; Fan, S. 2013: Mammalian target of rapamycin regulates androgen receptor and Akt phosphorylation in prostate cancer 22RV1 cells Zhonghua Nan Ke Xue 19(12): 1068-1071
Koivisto, P.; Kononen, J.; Palmberg, C.; Tammela, T.; Hyytinen, E.; Isola, J.; Trapman, J.; Cleutjens, K.; Noordzij, A.; Visakorpi, T.; Kallioniemi, O.P. 1997: Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer Cancer Research 57(2): 314-319
Gu, Y.; Kim, K-Hong.; Ko, D.; Srivastava, S.; Moul, J.W.; McLeod, D.G.; Rhim, J.S. 2005: Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line Anticancer Research 25(1a): 1-8
Hsieh, T-Chen.; Lu, X.; Guo, J.; Xiong, W.; Kunicki, J.; Darzynkiewicz, Z.; Wu, J.M. 2002: Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies International Journal of Oncology 20(4): 681-689
Bowery, N.G.; Doble, A.; Hill, D.R.; Hudson, A.L.; Turnbull, M.J.; Warrington, R. 1981: Structure/activity studies at a baclofen-sensitive, bicuculline-insensitive GABA receptor Advances in Biochemical Psychopharmacology 29: 333-341
Krieg, M.; Bartsch, W.; Herzer, S.; Becker, H.; Voigt, K.D. 1977: Quantification of androgen binding, androgen tissue levels, and sex hormone-binding globulin in prostate, muscle and plasma of patients with benign prostatic hypertrophy Acta Endocrinologica 86(1): 200-215
Shain, S.A.; Boesel, R.W.; Kalter, S.S.; Heberling, R.L. 1981: A x C rat prostate adenocarcinoma: initial characterization of testosterone regulation of hormone receptors of cultured cancer cells and derived tumors Journal of the National Cancer Institute 66(3): 565-574
Mao, C.; Merlin, G.; Aguet, M. 1990: Differential regulation of the human IFN-gamma receptor expression in Raji and IM9 lymphoblastoid cells versus THP-1 monocytic cells by IFN-gamma and phorbol myristate acetate Journal of Immunology 144(12): 4688-4696
Kopach, O.V.; Kruhlykov, I.A.; Voĭtenko, N.V.; Fedirko, N.V. 2005: Thapsigargin-sensitive and insensitive intracellular calcium stores in acinar cells of the submandibular salivary gland in rats Fiziolohichnyi Zhurnal 51(1): 62-71
Dondi, D.; Limonta, P.; Moretti, R.M.; Marelli, M.M.; Garattini, E.; Motta, M. 1994: Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop Cancer Research 54(15): 4091-4095