Development and progression of prostate cancer in relation with androgen dependency
Shimazaki, J.
Nihon Rinsho. Japanese Journal of Clinical Medicine 56(8): 1953-1958
1998
ISSN/ISBN: 0047-1852 PMID: 9750486 Document Number: 488045
Although carcinogen to human prostate cancer has not clarified yet, androgen is necessary for genetic damage on epithelial tissue of the prostate. There are many factors influencing promotion of cancer cells under certain androgenic environment; IGF, somatostatin, nutriments including beta-carotin, fat and green tea. Loss of androgen dependency gradually occur during progression. This may be attributable to adaptation, paracrine regulation and genetic change, but the latter is main course to acquire autonomous growth with metastatic ability. Mutation of androgen receptor which occurs in some cases plays a role on antiandrogen withdrawal syndrome.